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  • How-to guides
    New-U Research Compounds — Buy AOD-9604 at New-U Research Compounds. Laboratory research use only.

    Tissue and Cellular Models · Reviewed 16 June 2026

    Buy AOD-9604

    Also known as AOD9604, Anti-Obesity Drug 9604, Tyr-hGH Fragment 177-191, HGH Fragment Tyrosine Variant, Metabolic Pharmaceuticals AOD

    From $172 per 10-vial research pack · 10 × 5 mg · in stock

    Single vials from $38 , added to a pack order.

  • View full research profile
  • Compare all 4 formats
  • Certificate of Analysis
  • For laboratory and research use only — not for human or veterinary use. 21+.

    Inside New-U Research Compounds

    AOD-9604 at a glance

    Sequence
    Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
    Molecular weight
    1,815.10 Da
    Pathways studied
    β3-adrenergic receptor · Hormone-sensitive lipase · No GH receptor binding · N-terminal Tyr
    Purity
    >99% HPLC
    Form
    Lyophilised powder
    Formats
    10-vial research packs and single vials · 5–10 mg per vial
    Latest certificate
    Freedom Diagnostics, 9 February 2026 — 99.532% purity
    Laboratory storage
    Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation.

    What is AOD-9604?

    What AOD-9604 research examines

  • Tyrosine-modified HGH fragment with enhanced stability and lipolytic potency over native 176-191 sequence
  • Upregulates β3-adrenergic receptor expression in adipocytes, confirmed essential via β3-AR knockout studies
  • Stimulates HSL-mediated lipolysis and inhibits ACC-dependent lipogenesis simultaneously
  • Rapid insulin metabolism improvements observed in preclinical models prior to adipose tissue reduction
  • Summarised from published preclinical and clinical literature; findings describe study models, not uses of the research material.

    AOD-9604 price and pack sizes

    Strength per vial Format Price Cost per mg 5 mg 10-vial research pack $172 $3.44 5 mg Single vial $38 $7.60 10 mg 10-vial research pack $338 $3.38 10 mg Single vial $60 $6.00

    All packs are >99% HPLC research-grade material. Cost per mg is the price divided by the total mg in the pack. Single vials ship only as an add-on to an order that includes a 10-vial research pack. Flat $35 USD worldwide · free over $350 USD.

    Current AOD-9604 certificate

    The current published certificate for AOD-9604 is an independent Freedom Diagnostics report dated 9 February 2026.

    Laboratory Freedom Diagnostics Report date 9 February 2026 Purity 99.532% Report number 2602050113
  • View the AOD-9604 certificate and testing history
  • Download the report (PDF)
  • How to read a Certificate of Analysis
  • Certificates of Analysis are published on the website — on each product page and at /coa — rather than packed with orders. Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.

    Mechanism summary

    AOD-9604 triggers fat breakdown through the cAMP/PKA pathway and β3-adrenergic receptor upregulation, with no activity at the growth hormone receptor.

    Target or pathway Reported activity Research significance β3-adrenergic receptor Upregulates β3-AR mRNA in adipocytes Knockout studies confirm this is the required pathway for lipolytic effects Hormone-sensitive lipase Activates HSL via cAMP / PKA Breaks down stored triglycerides into free fatty acids N-terminal Tyr Tyr substitution enhances stability vs native fragment Gives improved lipolytic potency and shelf life over HGH Frag 176-191

    Evidence summary

    Evidence base: Mixed (human + animal)

    Human studies

  • Metabolic Pharmaceuticals clinical program - six randomised trials (~900 participants); a 12-week phase 2a reported significant weight loss (2.6 kg vs 0.8 kg placebo)
  • Animal and laboratory studies

  • Heffernan et al. (Endocrinology, 2001) - β3-adrenergic-receptor knockout mice were unresponsive to AOD-9604, establishing pathway dependence
  • Ng et al. (Horm Res, 2000) - metabolic studies of the synthetic lipolytic hGH domain (AOD9604) confirming lipolytic activity in animal models
  • Buying AOD-9604: ordering and delivery

    Delivery time
    Approximately 6–14 business days worldwide
    Dispatch
    Orders typically dispatch within 48 hours of confirmed payment.
    Ships from
    US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer.
    Shipping cost
    Flat $35 USD worldwide · free over $350 USD
    Payment
    Card, Apple Pay, Google Pay, Cash App, Cryptocurrency
    Packaging
    Discreet packaging
    In transit
    Lyophilised peptides are stable through the tracked transit window.
    Purchasers
    21+ · laboratory research use only

    Explore AOD-9604 research

    Published research, analytical evidence and comparisons for this compound. Research use only.

  • Research guide AOD-9604 research guide AOD-9604 triggers fat breakdown through the cAMP/PKA pathway and β3-adrenergic receptor upregulation, with no activity at the growth… Read the guide →
  • Analytical evidence View the AOD-9604 COA Current batch purity and identity testing, 2026-02-09. View the COA →
  • Compare Compare AOD-9604 and MOTS-C AOD-9604 vs MOTS-C: mechanism, receptor profile and specifications side by side. Compare →
  • Compare Compare AOD-9604 and Semaglutide AOD-9604 vs Semaglutide: mechanism, receptor profile and specifications side by side. Compare →
  • Frequently asked questions

    Where can I buy AOD-9604?

    AOD-9604 (also known as AOD9604) is available directly from New-U Research Compounds at https://new-u.io/peptide/aod-9604. It is supplied as lyophilised research-grade material; every released sale batch is independently verified by Janoshik Analytical and Freedom Diagnostics before it is offered for sale, and orders ship direct from source worldwide (approximately 6–14 business days).

    How much does AOD-9604 cost?

    AOD-9604 starts at $172 for a 10-vial research pack (5mg per vial) at New-U Research Compounds, with 4 pack sizes listed; single vials from $38 ship as an add-on to a pack order. Orders over $350 ship free.

    Is New-U AOD-9604 third-party tested?

    Yes. Released AOD-9604 batches are verified by independent laboratories (Janoshik Analytical and Freedom Diagnostics) for identity and purity before they are offered for sale. The current published certificate (Freedom Diagnostics, 9 February 2026) reports 99.532% purity and is published at https://new-u.io/coa/aod-9604.

    How fast does AOD-9604 ship, and do you ship internationally?

    AOD-9604 ships discreetly and tracked worldwide. US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer. Delivery takes approximately 6–14 business days worldwide. Shipping is free on orders over $350. Card and cryptocurrency payments are accepted.

    Is it legal to buy AOD-9604?

    In the United States, AOD-9604 is not approved by the FDA for human consumption and is not sold for that purpose. Research use only - all claims made on this site are for testing and research use only. Regulatory requirements vary by product, intended use and jurisdiction. Purchasers are responsible for ensuring that acquisition and use of research material complies with applicable requirements.

    What is the typical AOD-9604 research dosage?

    Reconstitution volumes and dosing reported in the literature for AOD-9604 are described in research-model terms only. New-U Research Compounds supplies AOD-9604 strictly for laboratory research and does not provide human-use dosing guidance. Reconstitution math and study-reported ranges are covered on the full research profile.

    What do I use to reconstitute AOD-9604?

    Lyophilised AOD-9604 is reconstituted with bacteriostatic water - sterile water with 0.9% benzyl alcohol, the standard multi-use diluent for research peptides. New-U supplies USP-grade bacteriostatic water at https://new-u.io/peptide/bacteriostatic-water, and a free reconstitution calculator at https://new-u.io/tracker/calculator works out the volume for any peptide.

    Can I buy AOD-9604 online and how fast does it ship?

    Yes. AOD-9604 can be ordered online directly from New-U Research Compounds with card or cryptocurrency, shipped direct from source discreetly worldwide. Delivery is approximately 6–14 business days worldwide. Free shipping applies to orders over $350.

    Can I buy AOD-9604 in bulk?

    AOD-9604 ships in 10-vial research packs as standard, in 4 pack sizes — the larger mg vials lower the per-mg cost. Multi-pack orders get direct-from-source pricing and free shipping over $350. For wholesale or recurring laboratory-supply volumes, contact New-U Research Compounds at https://new-u.io/contact.

    What should I look for when choosing where to buy AOD-9604?

    For research-grade AOD-9604, verify four things: (1) independent third-party purity testing with a published Certificate of Analysis - New-U uses Janoshik Analytical and Freedom Diagnostics; (2) lyophilised material with documented storage and handling; (3) transparent direct-from-source pricing rather than marketplace markup; and (4) clear research-use-only framing. New-U Research Compounds meets all four at https://new-u.io/peptide/aod-9604, and the current AOD-9604 certificate is at https://new-u.io/coa/aod-9604.

    What is AOD-9604?

    AOD-9604 is a synthetic, tyrosine-modified version of the C-terminal lipolytic fragment of human growth hormone (Tyr-hGH 177-191) - closely related to native with an added N-terminal tyrosine for stability and lipolytic potency. It was developed to target fat metabolism without the growth or IGF-1 effects of full HGH, and reached Phase 2b human obesity trials. Supplied as a lyophilised research-grade powder for laboratory use only.

    What does AOD-9604 do?

    In research models AOD-9604 stimulates lipolysis (fat breakdown) and inhibits lipogenesis via a β3-adrenergic-linked mechanism, reportedly without raising IGF-1 or affecting blood glucose the way full HGH does. These are findings in cell and animal models; New-U supplies it for laboratory research only and implies no human effect.

    Does AOD-9604 work?

    Early and animal research showed lipolytic activity, but the Phase 2b human obesity trial did not produce statistically significant weight loss versus placebo. So its real-world efficacy is unproven, and it is sold as a research compound only - not an approved weight-loss drug.

    How is AOD-9604 reconstituted?

    For laboratory preparation, dissolve the lyophilised powder in bacteriostatic water: concentration in mg/mL equals the vial mass in mg divided by the millilitres of diluent added. Keep the reconstituted vial refrigerated at 1–6 °C and protected from light. This is preparation math only; New-U provides no human-use dosing guidance.

    How is AOD-9604 different from HGH Fragment 176-191?

    AOD-9604 is the same lipolytic fragment with a tyrosine substituted for the N-terminal phenylalanine. The tyrosine substitution improves stability and lipolytic potency and was the design choice that enabled the molecule to progress through formal clinical trials as a distinct research entity.

    Does AOD-9604 raise IGF-1 or blood sugar?

    No - and this was a deliberate design goal. AOD-9604 does not bind the growth hormone receptor, so it does not trigger hepatic IGF-1 synthesis and does not produce the counter-regulatory insulin-opposing effects of full-length HGH. Clinical trials confirmed unchanged glycemic parameters.

    Why did the Phase 2b trial fail?

    The Phase 2b was an oral-dosing study at 0.25-1 mg/day, and those doses were likely too low to produce meaningful weight loss in humans - the earlier Phase 2a at different dosing had shown ~2.6 kg loss versus 0.8 kg placebo. The failure ended commercial development but did not change the preclinical mechanism data.

    How should AOD-9604 be stored?

    Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The disulfide-containing cyclic structure is reasonably stable but plan usage within the normal peptide-handling window.

    Research references

    Independent literature and reference sources for AOD-9604. Provided for scientific context - New-U Research Compounds supplies research-use-only material.

  • AOD-9604 — Wikipedia
  • Ng FM et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res.
  • Looking for mechanism of action, pharmacokinetics, dosage ranges and source references? See the full AOD-9604 research profile. Every compound profile is listed in the research peptide index.

    PRECISION. PURITY. PERFORMANCE.

    Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.

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  • Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.

    All rights reserved. Copyright of New-U held with Hilxera Distribution Services LLC 2026.

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    © 2026 New-U Research Compounds · new-u.io

    [image: New-U Research Compounds logo and research peptide vial — Buy AOD-9604 at New-U Research Compounds]

    [image: AOD-9604 research peptide vial — Healing / Recovery compound, >99% HPLC]

    Research use only — not for human consumption. All products are supplied strictly for laboratory research purposes.

    © 2026 New-U Research Compounds · new-u.io — Copyright held with Hilxera Distribution Services LLC. All rights reserved.