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    • How-to guides
    New-U Research Compounds — Buy CJC-1295 (without DAC) at New-U Research Compounds. Laboratory research use only.

    GH-Axis Research · Reviewed 16 June 2026

    Buy CJC-1295 (without DAC)

    Also known as Modified GRF 1-29, Mod GRF(1-29), CJC-1295 without DAC, Tetrasubstituted GRF(1-29), ModGRF

    CJC-1295 No DAC (Mod GRF 1-29), tetrasubstituted GHRH(1-29) analogue with DPP-IV resistance for acute pulsatile GH secretion research.

    From $172 per 10-vial research pack · 10 × 5 mg · in stock

    Single vials from $41 , added to a pack order.

  • View full research profile
  • Compare all 4 formats

    • For laboratory and research use only — not for human or veterinary use. 21+.

    Inside New-U Research Compounds

    CJC-1295 (without DAC) at a glance

    Sequence
    Tyr-DAla-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
    Molecular weight
    3,367.9 Da
    Pathways studied
    GHRH receptor · D-Ala2 substitution · Gln8 substitution · Leu27 substitution
    Purity
    >99% HPLC
    Form
    Lyophilised powder
    Formats
    10-vial research packs and single vials · 5–10 mg per vial
    Laboratory storage
    Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation.

    What is CJC-1295 (without DAC)?

    CJC-1295 without DAC (Modified GRF 1-29) is a short-acting tetrasubstituted GHRH analog that produces clean, physiologic growth hormone pulses without the week-long albumin-bound tail of the DAC version.

    What CJC-1295 (without DAC) research examines

  • Tetrasubstituted backbone provides DPP-IV resistance with 4-fold GH AUC increase over native GHRH(1-29)
  • Short 30-minute half-life produces acute pulsatile GH release mimicking endogenous GHRH kinetics
  • D-Ala2 substitution prevents dipeptidyl peptidase-IV cleavage at the N-terminus
  • Gln8 eliminates asparagine rearrangement and amide hydrolysis degradation pathways
  • Leu27 prevents methionine oxidation enhancing peptide shelf stability
  • Preserves somatostatin-regulated pulsatile GH secretion and hypothalamic-pituitary axis integrity

    • Summarised from published preclinical and clinical literature; findings describe study models, not uses of the research material.

    CJC-1295 (without DAC) price and pack sizes

    Strength per vial Format Price Cost per mg 5 mg 10-vial research pack $172 $3.44 5 mg Single vial $41 $8.20 10 mg 10-vial research pack $244 $2.44 10 mg Single vial $50 $5.00

    All packs are >99% HPLC research-grade material. Cost per mg is the price divided by the total mg in the pack. Single vials ship only as an add-on to an order that includes a 10-vial research pack. Flat $35 USD worldwide · free over $350 USD.

    CJC-1295 (without DAC) certificate status

    Every released sale batch must pass independent verification before it is offered for sale. A public certificate for CJC-1295 (without DAC) is not listed yet. Contact support with your order reference if a public certificate for your compound is not yet listed.

  • Browse published certificates
  • How to read a Certificate of Analysis

    • Mechanism summary

    Target or pathway Reported activity Research significance GHRH receptor Full agonist at the pituitary somatotroph GHRHR Drives cAMP-dependent GH exocytosis like native GHRH D-Ala2 substitution Blocks DPP-IV cleavage at the N-terminus Preserves the peptide through the main inactivation pathway Gln8 substitution Prevents asparagine rearrangement Stops a common aging/storage degradation route Leu27 substitution Eliminates methionine oxidation site Improves shelf stability and in-vivo robustness

    Pharmacokinetics at a glance

    Half-life ~30 min functional half-life (no albumin-binding DAC tag); GH pulse duration ~2 h Metabolism Proteolytic clearance - the tetrasubstitution (D-Ala2, Gln8, Ala15, Leu27) blocks DPP-IV cleavage, asparagine rearrangement and methionine oxidation

    The short pulse is intentional: pulsatile GHRH signalling avoids the receptor desensitisation (tachyphylaxis) seen with sustained stimulation, and ~4× GH AUC over unmodified GHRH(1-29) is retained.

    Evidence summary

    Evidence base: Tier 2: Animal / preclinical

    The short-acting no-DAC variant is supported mainly by mechanistic/animal data and the GHRH-analogue class; it has no dedicated human efficacy trials and is not approved. Supplied as unapproved research-grade material.

    Human studies

  • GHRH-analogue-class human pharmacodynamic context from the DAC sibling (Teichman et al., JCEM 2006)

    • Animal and laboratory studies

  • Jette et al. Endocrinology 2005 - tetrasubstituted GRF(1-29) chemistry and ~4× GH AUC

    • Buying CJC-1295 (without DAC): ordering and delivery

    Delivery time
    Approximately 6–14 business days worldwide
    Dispatch
    Orders typically dispatch within 48 hours of confirmed payment.
    Ships from
    US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer.
    Shipping cost
    Flat $35 USD worldwide · free over $350 USD
    Payment
    Card, Apple Pay, Google Pay, Cash App, Cryptocurrency
    Packaging
    Discreet packaging
    In transit
    Lyophilised peptides are stable through the tracked transit window.
    Purchasers
    21+ · laboratory research use only

    Explore CJC-1295 (without DAC) research

    Published research, analytical evidence and comparisons for this compound. Research use only.

  • Research guide CJC-1295 (without DAC) research guide Mod GRF 1-29 activates the GHRH receptor to produce a short, natural-shaped pulse of growth hormone, synergising with ghrelin-receptor… Read the guide →
  • Compare Compare CJC-1295 (without DAC) and CJC-1295 (with DAC) CJC-1295 (without DAC) vs CJC-1295 (with DAC): mechanism, receptor profile and specifications side by side. Compare →
  • Related research CJC-1295 & ipamorelin: a research guide to the GHRH + GHRP pair The most-studied GHRH + GHRP research combination. CJC-1295 with DAC vs no-DAC explained, ipamorelin’s selective ghrelin-receptor… Read the article →
  • Compare Compare CJC-1295 (without DAC) and Ipamorelin CJC-1295 (without DAC) vs Ipamorelin: mechanism, receptor profile and specifications side by side. Compare →
  • Related research Hexarelin vs CJC-1295: GHSR/CD36 Potency vs GHRH-R Signalling Hexarelin and CJC-1295 are two ends of the same GH axis - the ghrelin-receptor/CD36 arm against the GHRH-receptor arm. Mechanism… Read the article →

    • Frequently asked questions

    Where can I buy CJC-1295 (without DAC)?

    CJC-1295 (without DAC) (also known as Modified GRF 1-29) is available directly from New-U Research Compounds at https://new-u.io/peptide/cjc-1295-no-dac. It is supplied as lyophilised research-grade material; every released sale batch is independently verified by Janoshik Analytical and Freedom Diagnostics before it is offered for sale, and orders ship direct from source worldwide (approximately 6–14 business days).

    How much does CJC-1295 (without DAC) cost?

    CJC-1295 (without DAC) starts at $172 for a 10-vial research pack (5mg per vial) at New-U Research Compounds, with 4 pack sizes listed; single vials from $41 ship as an add-on to a pack order. Orders over $350 ship free.

    Is New-U CJC-1295 (without DAC) third-party tested?

    Yes. Released CJC-1295 (without DAC) batches are verified by independent laboratories (Janoshik Analytical and Freedom Diagnostics) for identity and purity before they are offered for sale. A public certificate for CJC-1295 (without DAC) is not listed yet. Contact support with your order reference if a public certificate for your compound is not yet listed.

    How fast does CJC-1295 (without DAC) ship, and do you ship internationally?

    CJC-1295 (without DAC) ships discreetly and tracked worldwide. US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer. Delivery takes approximately 6–14 business days worldwide. Shipping is free on orders over $350. Card and cryptocurrency payments are accepted.

    Is it legal to buy CJC-1295 (without DAC)?

    In the United States, CJC-1295 (without DAC) is not approved by the FDA for human consumption and is not sold for that purpose. Research use only - all claims made on this site are for testing and research use only. Regulatory requirements vary by product, intended use and jurisdiction. Purchasers are responsible for ensuring that acquisition and use of research material complies with applicable requirements.

    What is CJC-1295 (without DAC) used for in research?

    CJC-1295 No DAC (Mod GRF 1-29), tetrasubstituted GHRH(1-29) analogue with DPP-IV resistance for acute pulsatile GH secretion research. New-U supplies CJC-1295 (without DAC) as research-grade reference material for laboratory and in-vitro or animal-model investigation only. Mechanism, pharmacokinetics and study context are summarised on the CJC-1295 (without DAC) research profile.

    What is the typical CJC-1295 (without DAC) research dosage?

    Reconstitution volumes and dosing reported in the literature for CJC-1295 (without DAC) are described in research-model terms only. New-U Research Compounds supplies CJC-1295 (without DAC) strictly for laboratory research and does not provide human-use dosing guidance. Reconstitution math and study-reported ranges are covered on the full research profile.

    What do I use to reconstitute CJC-1295 (without DAC)?

    Lyophilised CJC-1295 (without DAC) is reconstituted with bacteriostatic water - sterile water with 0.9% benzyl alcohol, the standard multi-use diluent for research peptides. New-U supplies USP-grade bacteriostatic water at https://new-u.io/peptide/bacteriostatic-water, and a free reconstitution calculator at https://new-u.io/tracker/calculator works out the volume for any peptide.

    Can I buy CJC-1295 (without DAC) online and how fast does it ship?

    Yes. CJC-1295 (without DAC) can be ordered online directly from New-U Research Compounds with card or cryptocurrency, shipped direct from source discreetly worldwide. Delivery is approximately 6–14 business days worldwide. Free shipping applies to orders over $350.

    Can I buy CJC-1295 (without DAC) in bulk?

    CJC-1295 (without DAC) ships in 10-vial research packs as standard, in 4 pack sizes — the larger mg vials lower the per-mg cost. Multi-pack orders get direct-from-source pricing and free shipping over $350. For wholesale or recurring laboratory-supply volumes, contact New-U Research Compounds at https://new-u.io/contact.

    What should I look for when choosing where to buy CJC-1295 (without DAC)?

    For research-grade CJC-1295 (without DAC), verify four things: (1) independent third-party purity testing with a published Certificate of Analysis - New-U uses Janoshik Analytical and Freedom Diagnostics; (2) lyophilised material with documented storage and handling; (3) transparent direct-from-source pricing rather than marketplace markup; and (4) clear research-use-only framing. New-U Research Compounds lists CJC-1295 (without DAC) at https://new-u.io/peptide/cjc-1295-no-dac. A public CJC-1295 (without DAC) certificate is not listed yet; support answers certificate questions from the order reference.

    Can I buy CJC-1295 (without DAC) and Ipamorelin together?

    Yes. New-U Research Compounds supplies both CJC-1295 (without DAC) and Ipamorelin as separate research-grade vials. The CJC-1295 (no DAC / Mod GRF 1-29) GHRH analogue and the selective GHSR-1a agonist Ipamorelin are the classic co-studied growth-hormone-axis pair, combining a GHRH signal with a ghrelin-mimetic signal. Order CJC-1295 (without DAC) at https://new-u.io/peptide/cjc-1295-no-dac and Ipamorelin at https://new-u.io/peptide/ipamorelin.

    What is CJC-1295 (without DAC)?

    CJC-1295 without DAC (also called Modified GRF 1-29) is a tetrasubstituted analogue of growth-hormone-releasing hormone, GHRH(1-29). Unlike the DAC version it has no albumin-binding tag, so it is short-acting (~30 min) and drives a physiologic, pulse-like release of growth hormone. Supplied as a lyophilised research-grade powder for laboratory use only.

    What does CJC-1295 do?

    In research models CJC-1295 binds the pituitary GHRH receptor and stimulates growth-hormone (and downstream IGF-1) release. The no-DAC form produces short, natural-shaped GH pulses; the DAC form sustains the signal for days. These are findings in cell and animal models; New-U supplies it for laboratory research only.

    Is CJC-1295 safe?

    In published animal studies CJC-1295 has generally been well tolerated, but there are no controlled human safety trials, so human safety is not established. It is a research compound, not a medicine; New-U makes no human-use claims and supplies it for laboratory research only.

    What is the difference between CJC-1295 and "Modified GRF 1-29"?

    They are the same peptide - a tetrasubstituted GHRH(1-29) without the DAC albumin-binding tag. "Modified GRF 1-29" is the older research name; "CJC-1295 without DAC" became the common marketplace name after the DAC version entered clinical development.

    Why is CJC-1295 no DAC usually stacked with ipamorelin?

    The two peptides activate different receptors (GHRHR vs GHSR) that synergise in GH release. Combining a GHRH analog with a ghrelin-receptor agonist produces a larger, cleaner GH pulse than either peptide alone - this is the standard research pairing in the literature.

    Does the short half-life mean it is worse than the DAC version?

    No - just different. The DAC version is for sustained elevation over days; the no-DAC version is for sharp, physiologic pulses. Which one is appropriate depends on the research question, not on which is "stronger".

    Is CJC-1295 (no DAC) the same as sermorelin or tesamorelin?

    They are related but not identical. All three are GHRH-based peptides that act on the pituitary GHRH receptor. Sermorelin is the unmodified GHRH(1-29) fragment; CJC-1295 no DAC (Modified GRF 1-29) is that same fragment with four stabilising substitutions that resist breakdown and raise GH output; tesamorelin is a separate stabilised GHRH analogue that reached approval for a specific indication. The no-DAC form is studied for its short, pulsatile profile.

    How should CJC-1295 no DAC be stored?

    Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The four stabilising substitutions make it more robust than native GHRH(1-29), but standard peptide handling still applies.

    What happens if you stop taking peptides?

    CJC-1295 (no DAC / Modified GRF 1-29) is a short-acting GHRH analogue that prompts the pituitary's own GH pulses. Because its half-life is minutes, the research indicates it clears almost immediately once administration stops, and the GH/IGF-1 axis returns toward its pre-treatment baseline without the suppression seen after exogenous HGH. Effects observed in a study simply lose their stimulus. These are research observations.

    Research references

    Independent literature and reference sources for CJC-1295 (without DAC). Provided for scientific context - New-U Research Compounds supplies research-use-only material.

  • CJC-1295 (without DAC) — Wikipedia
  • Teichman SL et al. Prolonged Stimulation of GH and IGF-I Secretion by CJC-1295 (DAC sibling) in Healthy Adults. J Clin Endocrinol Metab.

    • Looking for mechanism of action, pharmacokinetics, dosage ranges and source references? See the full CJC-1295 (without DAC) research profile. Every compound profile is listed in the research peptide index.

    Part of the Growth hormone secretagogue research research area — explore related compounds, guides and sources.

    PRECISION. PURITY. PERFORMANCE.

    Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.

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    • Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.

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    Principal office: 1712 Pioneer Ave., Ste. 500, Cheyenne, WY 82001, USA

    © 2026 New-U Research Compounds · new-u.io

    [image: New-U Research Compounds logo and research peptide vial — Buy CJC-1295 (without DAC) at New-U Research Compounds]

    [image: CJC-1295 (without DAC) research peptide vial — HGH / Somatropin compound, >99% HPLC]

    Research use only — not for human consumption. All products are supplied strictly for laboratory research purposes.

    © 2026 New-U Research Compounds · new-u.io — Copyright held with Hilxera Distribution Services LLC. All rights reserved.