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    • How-to guides
    New-U Research Compounds — Buy Semaglutide at New-U Research Compounds. Laboratory research use only.

    Metabolic Research · Reviewed 14 August 2026

    Semaglutide Research

    GLP1-RC-SM Laboratory Research Material

    Also known as Semaglutide Acetate, GLP-1 Receptor Agonist

    Semaglutide is a long-acting GLP-1 receptor agonist characterised in published research, with 94% homology to native human GLP-1 and a C18 fatty-diacid albumin-binding modification. GLP1-RC-SM is the New-U catalogue identifier for the analytically verified laboratory research material supplied here.

    From $158 per 10-vial research pack · 10 × 5 mg · in stock

    Single vials from $47 , added to a pack order.

  • View full research profile
  • Compare all 10 formats
  • Certificate of Analysis

    • For laboratory and research use only — not for human or veterinary use. 21+.

    Inside New-U Research Compounds

    Semaglutide at a glance

    Catalogue identifier
    GLP1-RC-SM (“Sema”)
    Compound class
    GLP-1R agonist research compound
    Sequence
    His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18-diacid-γGlu-miniPEG)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
    Molecular weight
    4,113.58 Da
    Purity
    >99% HPLC
    Form
    Lyophilised powder
    Formats
    10-vial research packs and single vials · 5–30 mg per vial
    Latest certificate
    Janoshik Analytical, 30 April 2025 — 99.358% purity
    Laboratory storage
    Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation.

    GLP1-RC-SM Research Material

    GLP1-RC-SM is New-U’s catalogue identifier for the laboratory research material offered through this page.

    Published Semaglutide research discussed below relates to external investigational studies and their study materials and protocols.

    GLP1-RC-SM is not offered as a medicine, treatment or therapeutic product and is not intended for human or veterinary use.

    What is Semaglutide?

    Semaglutide is a GLP-1 receptor agonist characterised in published clinical research and approved as a medicine in some jurisdictions under other manufacturers’ brand names.

    GLP1-RC-SM is a GLP-1R agonist research compound, commonly referred to as “Sema” in research communities.

    Semaglutide price and pack sizes

    Strength per vial Format Price Cost per mg 5 mg 10-vial research pack $158 $3.16 5 mg Single vial $47 $9.40 10 mg 10-vial research pack $215 $2.15 10 mg Single vial $65 $6.50 15 mg 10-vial research pack $230 $1.53 15 mg Single vial $68 $4.53 20 mg 10-vial research pack $282 $1.41 20 mg Single vial $85 $4.25 30 mg 10-vial research pack $350 $1.17 30 mg Single vial $105 $3.50

    All packs are >99% HPLC research-grade material. Cost per mg is the price divided by the total mg in the pack. Single vials ship only as an add-on to an order that includes a 10-vial research pack. Flat $35 USD worldwide · free over $350 USD.

    Current Semaglutide certificate

    The current published certificate for GLP1-RC-SM research material is an independent Janoshik Analytical report dated 30 April 2025.

    Laboratory Janoshik Analytical Report date 30 April 2025 Purity 99.358% Report number 63609
  • View the Semaglutide certificate and testing history
  • Download the report (PDF)
  • How to read a Certificate of Analysis

    • Certificates of Analysis are published on the website — on each product page and at /coa — rather than packed with orders. Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.

    Mechanism summary

    Published experimental work characterises GLP-1R agonist activity, with an albumin-binding structural modification investigated as a contributor to prolonged systemic exposure.

    Target or pathway Reported activity Research significance GLP-1R (pancreatic β-cells) Agonist activity characterised in receptor pharmacology studies Glucose-dependent insulin secretion is the defining incretin property recorded in the literature GLP-1R (pancreatic α-cells) Agonist activity characterised experimentally Glucagon suppression recorded as a measured pharmacodynamic endpoint GLP-1R (gastrointestinal tract) Agonist activity characterised experimentally Delayed gastric emptying recorded as a measured pharmacodynamic endpoint GLP-1R (hypothalamus) POMC/CART activation and AgRP/NPY inhibition characterised in preclinical models The central signalling arm measured in energy-intake studies Albumin-binding modification C18 fatty diacid via a γGlu/mini-PEG spacer; >99% plasma protein binding reported Investigated as a contributor to prolonged systemic exposure (~7-day apparent half-life) Proteolytic stability Aib8 and Arg34 substitutions Structural modifications investigated for altered peptide stability against DPP-IV

    Pharmacokinetics at a glance

    Half-life Apparent elimination half-life reported at approximately 7 days (165–184 h); steady-state exposure reported after 4–5 weeks Metabolism Proteolytic cleavage of the peptide backbone plus β-oxidation of the C18 fatty-diacid chain reported; no CYP-mediated interactions; ~3% reported excreted unchanged in urine

    Evidence summary

    Evidence base: Tier 1: Human clinical

    The evidence tier describes the published literature on Semaglutide, the scientific subject, and specifically on the finished pharmaceutical studied in those trials. Published clinical findings summarised on this page relate to the investigational materials and protocols used in those external studies. They do not establish the safety, efficacy, intended use or clinical equivalence of New-U GLP1-RC-SM research material.

    Human studies

  • STEP-1 weight-management RCT — −14.9% mean change from baseline in body weight at week 68 (NEJM 2021; PMID 33567185)
  • SELECT cardiovascular-outcomes RCT — 17,604 participants (NEJM 2023; PMID 37952131)

    • Buying Semaglutide: ordering and delivery

    Delivery time
    Approximately 6–14 business days worldwide
    Dispatch
    Orders typically dispatch within 48 hours of confirmed payment.
    Ships from
    US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer.
    Shipping cost
    Flat $35 USD worldwide · free over $350 USD
    Payment
    Card, Apple Pay, Google Pay, Cash App, Cryptocurrency
    Packaging
    Discreet packaging
    In transit
    Lyophilised peptides are stable through the tracked transit window.
    Purchasers
    21+ · laboratory research use only

    Explore Semaglutide research

    Published research, analytical evidence and comparisons for this compound. Research use only.

  • Research guide Semaglutide research guide Published experimental work characterises GLP-1R agonist activity, with an albumin-binding structural modification investigated as a… Read the guide →
  • Analytical evidence View the Semaglutide COA Current batch purity and identity testing, 2025-04-30. View the COA →
  • Compare Compare Semaglutide and Retatrutide Semaglutide vs Retatrutide: mechanism, receptor profile and specifications side by side. Compare →
  • Related research Retatrutide vs semaglutide: triple agonist vs GLP-1, compared Triple (GIP/GLP-1/glucagon) vs single GLP-1 agonism, the Phase 2/3 weight-loss data (24.2% vs 14.9%), regulatory status and side effects… Read the article →
  • Compare Compare Semaglutide and Tirzepatide Semaglutide vs Tirzepatide: mechanism, receptor profile and specifications side by side. Compare →

    • Frequently asked questions

    Where can I buy Semaglutide?

    Semaglutide (also known as Semaglutide Acetate) is available directly from New-U Research Compounds at https://new-u.io/peptide/semaglutide. It is supplied as lyophilised research-grade material; every released sale batch is independently verified by Janoshik Analytical and Freedom Diagnostics before it is offered for sale, and orders ship direct from source worldwide (approximately 6–14 business days).

    How much does Semaglutide cost?

    Semaglutide starts at $158 for a 10-vial research pack (5mg per vial) at New-U Research Compounds, with 10 pack sizes listed; single vials from $47 ship as an add-on to a pack order. Orders over $350 ship free.

    Is New-U Semaglutide third-party tested?

    Yes. Released Semaglutide batches are verified by independent laboratories (Janoshik Analytical and Freedom Diagnostics) for identity and purity before they are offered for sale. The current published certificate (Janoshik Analytical, 30 April 2025) reports 99.358% purity and is published at https://new-u.io/coa/semaglutide.

    How fast does Semaglutide ship, and do you ship internationally?

    Semaglutide ships discreetly and tracked worldwide. US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer. Delivery takes approximately 6–14 business days worldwide. Shipping is free on orders over $350. Card and cryptocurrency payments are accepted.

    Is it legal to buy Semaglutide?

    GLP1-RC-SM is supplied strictly as laboratory research material and is not offered for human or veterinary use. Research use only - all claims made on this site are for testing and research use only. Regulatory requirements vary by product, intended use and jurisdiction. Purchasers are responsible for ensuring that acquisition and use of research material complies with applicable requirements.

    What is Semaglutide used for in research?

    Semaglutide is a long-acting GLP-1 receptor agonist characterised in published research, with 94% homology to native human GLP-1 and a C18 fatty-diacid albumin-binding modification. GLP1-RC-SM is the New-U catalogue identifier for the analytically verified laboratory research material supplied here. New-U supplies Semaglutide as research-grade reference material for laboratory and in-vitro or animal-model investigation only. Mechanism, pharmacokinetics and study context are summarised on the Semaglutide research profile.

    What analytical documentation is available for GLP1-RC-SM?

    Certificates of Analysis are published on the website — on each product page and at /coa — rather than packed with orders. Each published certificate records the independent laboratory, report number, RP-HPLC purity result, mass-spectrometry identity confirmation and test date; the current GLP1-RC-SM certificate is at https://new-u.io/coa/semaglutide, so you can check it before you order. Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.

    Does published Semaglutide clinical research apply to GLP1-RC-SM?

    No. Published clinical findings summarised on this page relate to the investigational materials and protocols used in those external studies. They do not establish the safety, efficacy, intended use or clinical equivalence of New-U GLP1-RC-SM research material. The two evidence types are kept separate on this page for that reason: batch analysis is New-U's own analytical work on the supplied lot, and the trial data is external work on the investigational or approved material those studies used.

    Can I buy Semaglutide online and how fast does it ship?

    Yes. Semaglutide can be ordered online directly from New-U Research Compounds with card or cryptocurrency, shipped direct from source discreetly worldwide. Delivery is approximately 6–14 business days worldwide. Free shipping applies to orders over $350.

    Can I buy Semaglutide in bulk?

    Semaglutide ships in 10-vial research packs as standard, in 10 pack sizes — the larger mg vials lower the per-mg cost. Multi-pack orders get direct-from-source pricing and free shipping over $350. For wholesale or recurring laboratory-supply volumes, contact New-U Research Compounds at https://new-u.io/contact.

    What should I look for when choosing where to buy Semaglutide?

    For research-grade Semaglutide, verify four things: (1) independent third-party purity testing with a published Certificate of Analysis - New-U uses Janoshik Analytical and Freedom Diagnostics; (2) lyophilised material with documented storage and handling; (3) transparent direct-from-source pricing rather than marketplace markup; and (4) clear research-use-only framing. New-U Research Compounds meets all four at https://new-u.io/peptide/semaglutide, and the current Semaglutide certificate is at https://new-u.io/coa/semaglutide.

    What is Semaglutide in scientific research?

    Semaglutide is a 31-amino-acid GLP-1 receptor agonist characterised in published receptor-pharmacology and clinical research. It is approved as a medicine in some jurisdictions under other manufacturers' brand names; the material supplied here is not that finished pharmaceutical.

    What is GLP1-RC-SM?

    GLP1-RC-SM is New-U's catalogue identifier for the laboratory research material offered through this research profile. It is not a medicine, a treatment, a generic pharmaceutical or a therapeutic product, it is not equivalent to any clinical or commercial product, and it is not offered for human or veterinary use.

    Which receptor systems are examined in Semaglutide research?

    Published work characterises agonist activity at the GLP-1 receptor across four tissue contexts: pancreatic β-cells (glucose-dependent insulin secretion), pancreatic α-cells (glucagon suppression), the gastrointestinal tract (delayed gastric emptying) and hypothalamic circuits (POMC/CART activation, AgRP/NPY inhibition in preclinical models). Structural work additionally investigates the C18 fatty-diacid albumin-binding modification and the Aib8 substitution for altered proteolytic stability.

    What analytical testing accompanies GLP1-RC-SM?

    Each released GLP1-RC-SM batch is tested by an independent analytical laboratory for purity by RP-HPLC area normalisation and for identity by mass spectrometry, and the result is published as a batch-linked Certificate of Analysis recording the laboratory, report number, measured purity and test date. Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.

    Where can I view the current batch COA for GLP1-RC-SM?

    The current batch certificate — laboratory, report number, measured purity and test date — is published at /coa/semaglutide, together with the testing history for the compound.

    What does >99% HPLC purity mean?

    It is a purity figure obtained by reversed-phase high-performance liquid chromatography using area normalisation: the target peak accounts for more than 99% of the total integrated peak area in the chromatogram for the tested sample. It is a statement about chemical purity of that sample only, and says nothing about sterility, endotoxin content, pharmaceutical equivalence or any clinical property.

    What clinical trials are referenced on this page?

    Five external studies of the reference medicine: STEP-1 (Wilding et al., NEJM 2021; PMID 33567185), SELECT (Lincoff et al., NEJM 2023; PMID 37952131), FLOW (Perkovic et al., NEJM 2024; DOI 10.1056/NEJMoa2403347), SOUL (McGuire et al., NEJM 2025; DOI 10.1056/NEJMoa2501006) and the structural paper by Lau et al. (J Med Chem 2015). Each reported result on this page is attributed to its study, arm and timepoint.

    How is published clinical research distinguished from New-U batch testing?

    They are separate bodies of evidence. Published clinical research is external work on the approved finished pharmaceutical, conducted under those studies' own protocols; it establishes nothing about the material supplied here. New-U batch testing is analytical work on the GLP1-RC-SM lot itself — RP-HPLC purity and mass-spectrometry identity — and it establishes nothing clinical. A certificate of analysis combined with an external clinical paper does not amount to clinical validation of GLP1-RC-SM.

    Is GLP1-RC-SM the same as an approved branded medicine?

    No. Approved branded semaglutide products are prescription, sterile finished pharmaceuticals manufactured under cGMP by their marketing authorisation holders. GLP1-RC-SM is unapproved laboratory research material supplied as a lyophilised powder. It is not equivalent to, a generic of, or a substitute for any approved product.

    How is Semaglutide different from native GLP-1?

    Published structural work describes 94% sequence homology with native human GLP-1(7-37) plus three engineered modifications: an Aib substitution at position 8 investigated for DPP-IV resistance, an Arg substitution at position 34, and a C18 fatty diacid attached at Lys26. The fatty acid is reported to bind albumin, which the literature attributes the extension of apparent half-life from roughly 2 minutes to approximately 7 days to.

    What form is GLP1-RC-SM supplied in?

    GLP1-RC-SM is supplied as a lyophilised powder in sealed vials, in sealed 10-vial research packs across the listed strengths; the batch-linked Certificate of Analysis is published on the product page.

    How should laboratory research material be stored?

    Store the lyophilised powder in a freezer at −20 °C. If a laboratory protocol requires the material in solution, hold the resulting solution refrigerated at 1–6 °C, protected from light, and avoid repeated warming and cooling cycles, which can degrade the fatty-acid modification. Storage conditions are laboratory handling information only.

    Is Semaglutide research compared head-to-head with Tirzepatide research?

    One published trial, SURMOUNT-5 (NEJM 2025), was designed as a head-to-head comparison and reported a larger mean change from baseline in body weight in the tirzepatide arm than the semaglutide arm at week 72 (−20.2% vs −13.7%). Results from separate trials of the two compounds are not head-to-head comparisons and the study designs do not support treating them as such.

    Research references

    Independent literature and reference sources for Semaglutide. Provided for scientific context - New-U Research Compounds supplies research-use-only material.

  • Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP-1). N Engl J Med.
  • Lincoff AM et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT). N Engl J Med.
  • Perkovic V et al. Effects of Semaglutide on Chronic Kidney Disease in Type 2 Diabetes (FLOW). N Engl J Med.
  • McGuire DK et al. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes (SOUL). N Engl J Med.
  • Lau J et al. Discovery of the Once-Weekly GLP-1 Analogue Semaglutide. J Med Chem.

    • Looking for receptor pharmacology, pharmacokinetics, registered clinical research and references? See the full Semaglutide research profile. Every compound profile is listed in the research peptide index.

    Part of the Metabolic & GLP-1 research research area — explore related compounds, guides and sources.

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    Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.

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    • Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.

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    © 2026 New-U Research Compounds · new-u.io

    [image: New-U Research Compounds logo and research peptide vial — Buy Semaglutide at New-U Research Compounds]

    [image: Semaglutide research peptide vial — Metabolic Research compound, >99% HPLC]

    Research use only — not for human consumption. All products are supplied strictly for laboratory research purposes.

    © 2026 New-U Research Compounds · new-u.io — Copyright held with Hilxera Distribution Services LLC. All rights reserved.