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Regenerative Research · Reviewed 16 June 2026
Buy TB-500
Also known as Thymosin Beta-4 Fragment, Tβ4, TB4, Fequesetide, Ac-LKKTETQ, Thymosin β4 Active Fragment, Actin-Binding Peptide
TB-500 synthetic Thymosin Beta-4 fragment studied for systemic tissue-repair activity via G-actin sequestration, angiogenesis, and NF-κB-mediated anti-inflammatory signaling.
From $188 per 10-vial research pack · 10 × 5 mg · in stock
Single vials from $56 , added to a pack order.
For laboratory and research use only — not for human or veterinary use. 21+.
Inside New-U Research Compounds
TB-500 at a glance
What is TB-500?
TB-500 is a synthetic acetylated heptapeptide fragment derived from the actin-binding region of Thymosin Beta-4, studied in preclinical models of tissue repair, cell migration, angiogenesis, and inflammatory signalling.
What TB-500 research examines
Summarised from published preclinical and clinical literature; findings describe study models, not uses of the research material.
TB-500 price and pack sizes
All packs are >99% HPLC research-grade material. Cost per mg is the price divided by the total mg in the pack. Single vials ship only as an add-on to an order that includes a 10-vial research pack. Flat $35 USD worldwide · free over $350 USD.
Current TB-500 certificate
The current published certificate for TB-500 is an independent Janoshik Analytical report dated 29 January 2026.
Certificates of Analysis are published on the website — on each product page and at /coa — rather than packed with orders. Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.
Mechanism summary
TB-500 binds loose (G-) actin inside cells and tunes down the inflammatory master switch NF-κB, helping cells migrate into damaged tissue and dampening the local inflammatory response.
Pharmacokinetics at a glance
Full-length Thymosin Beta-4 MW 4921 Da (43 aa); the TB-500 fragment MW 889 Da (7 aa). As an intrinsically unstructured peptide it adopts minimal secondary structure in solution.
Evidence summary
Evidence base: Tier 2: Animal / preclinical
Human studies
Animal and laboratory studies
Buying TB-500: ordering and delivery
Explore TB-500 research
Published research, analytical evidence and comparisons for this compound. Research use only.
Frequently asked questions
Where can I buy TB-500?
TB-500 (also known as Thymosin Beta-4 Fragment) is available directly from New-U Research Compounds at https://new-u.io/peptide/tb-500. It is supplied as lyophilised research-grade material; every released sale batch is independently verified by Janoshik Analytical and Freedom Diagnostics before it is offered for sale, and orders ship direct from source worldwide (approximately 6–14 business days).
How much does TB-500 cost?
TB-500 starts at $188 for a 10-vial research pack (5mg per vial) at New-U Research Compounds, with 4 pack sizes listed; single vials from $56 ship as an add-on to a pack order. Orders over $350 ship free.
Is New-U TB-500 third-party tested?
Yes. Released TB-500 batches are verified by independent laboratories (Janoshik Analytical and Freedom Diagnostics) for identity and purity before they are offered for sale. The current published certificate (Janoshik Analytical, 29 January 2026) reports 99.741% purity and is published at https://new-u.io/coa/tb-500.
How fast does TB-500 ship, and do you ship internationally?
TB-500 ships discreetly and tracked worldwide. US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer. Delivery takes approximately 6–14 business days worldwide. Shipping is free on orders over $350. Card and cryptocurrency payments are accepted.
Is it legal to buy TB-500?
In the United States, TB-500 is not approved by the FDA for human consumption and is not sold for that purpose. Research use only - all claims made on this site are for testing and research use only. Regulatory requirements vary by product, intended use and jurisdiction. Purchasers are responsible for ensuring that acquisition and use of research material complies with applicable requirements.
What is TB-500 used for in research?
TB-500 synthetic Thymosin Beta-4 fragment studied for systemic tissue-repair activity via G-actin sequestration, angiogenesis, and NF-κB-mediated anti-inflammatory signaling. New-U supplies TB-500 as research-grade reference material for laboratory and in-vitro or animal-model investigation only. Mechanism, pharmacokinetics and study context are summarised on the TB-500 research profile.
What is the typical TB-500 research dosage?
Reconstitution volumes and dosing reported in the literature for TB-500 are described in research-model terms only. New-U Research Compounds supplies TB-500 strictly for laboratory research and does not provide human-use dosing guidance. Reconstitution math and study-reported ranges are covered on the full research profile.
What do I use to reconstitute TB-500?
Lyophilised TB-500 is reconstituted with bacteriostatic water - sterile water with 0.9% benzyl alcohol, the standard multi-use diluent for research peptides. New-U supplies USP-grade bacteriostatic water at https://new-u.io/peptide/bacteriostatic-water, and a free reconstitution calculator at https://new-u.io/tracker/calculator works out the volume for any peptide.
Can I buy TB-500 online and how fast does it ship?
Yes. TB-500 can be ordered online directly from New-U Research Compounds with card or cryptocurrency, shipped direct from source discreetly worldwide. Delivery is approximately 6–14 business days worldwide. Free shipping applies to orders over $350.
Can I buy TB-500 in bulk?
TB-500 ships in 10-vial research packs as standard, in 4 pack sizes — the larger mg vials lower the per-mg cost. Multi-pack orders get direct-from-source pricing and free shipping over $350. For wholesale or recurring laboratory-supply volumes, contact New-U Research Compounds at https://new-u.io/contact.
What should I look for when choosing where to buy TB-500?
For research-grade TB-500, verify four things: (1) independent third-party purity testing with a published Certificate of Analysis - New-U uses Janoshik Analytical and Freedom Diagnostics; (2) lyophilised material with documented storage and handling; (3) transparent direct-from-source pricing rather than marketplace markup; and (4) clear research-use-only framing. New-U Research Compounds meets all four at https://new-u.io/peptide/tb-500, and the current TB-500 certificate is at https://new-u.io/coa/tb-500.
Can I buy TB-500 and BPC-157 together (the "Wolverine stack")?
Yes. New-U Research Compounds supplies both TB-500 and BPC-157 as separate research-grade vials. They are studied together because they support tissue repair through different mechanisms - TB-500 through actin regulation, angiogenesis, and NF-κB modulation, and BPC-157 through the VEGFR2/eNOS pathway and growth-hormone-receptor upregulation. Order TB-500 at https://new-u.io/peptide/tb-500 and BPC-157 at https://new-u.io/peptide/bpc-157.
What is TB-500?
TB-500 is a synthetic seven-amino-acid peptide (Ac-LKKTETQ) corresponding to the actin-binding region of Thymosin Beta-4, a protein found naturally in most human cells. It is made by solid-phase peptide synthesis and supplied as a lyophilised research-grade powder.
What does TB-500 do?
In preclinical research TB-500 is studied as a tissue-repair and cell-migration peptide. Published animal studies report regulation of G-actin (cytoskeletal remodelling), promotion of angiogenesis (new blood-vessel growth), endothelial and keratinocyte migration, and modulation of NF-κB-driven inflammation. These are findings in cell and animal models, not demonstrated human effects.
What is TB-500 used for?
In the research literature TB-500 is used as a tool compound to study tendon, ligament, muscle, cardiac and wound-tissue repair, plus cell migration and angiogenesis. New-U supplies it strictly for in-vitro and animal-model research.
Is TB-500 safe?
In published animal studies TB-500 has generally been well tolerated, but there are no controlled human safety trials, so human safety is not established. It is also WADA-prohibited for competing athletes.
How much TB-500 is used in research?
Experimental parameters in the published literature vary widely by model, species, route, formulation and study endpoint, so there is no single standard figure. Any quantities reported in studies are experimental parameters from controlled research settings only - New-U does not provide human-use dosing, administration, cycle, or protocol guidance.
What is the difference between TB-500 and Thymosin Beta-4?
Thymosin Beta-4 is the full 43-amino-acid protein found naturally in most human cells. TB-500 is a synthetic seven-amino-acid fragment (Ac-LKKTETQ) that preserves the actin-binding domain responsible for most of the parent protein's wound-healing activity. The shorter peptide is much cheaper to synthesise and is widely used as a research surrogate.
How does TB-500 compare with BPC-157?
Both are research peptides in the healing category but they act through different mechanisms. BPC-157 primarily drives VEGFR2/eNOS and FAK signalling, while TB-500 works through actin regulation and NF-κB modulation. Many preclinical protocols combine them to exploit the distinct pathways.
Is TB-500 approved for human use?
No. TB-500 is an investigational research peptide and is not approved for human therapeutic use by any major regulator. It is also on the World Anti-Doping Agency (WADA) prohibited list for competing athletes.
How should TB-500 research material be stored?
Store the lyophilised powder frozen and protected from light. Once placed into solution under laboratory conditions, keep it cold (1–6 °C) and protected from light, and follow the batch-specific handling documentation. Peptide material degrades slowly under cold, dark storage.
What vial sizes does New-U offer for TB-500, and how is it reconstituted?
New-U supplies TB-500 in 10-vial research packs at 5 mg and 10 mg per vial, with the larger vials lowering the per-mg cost. For laboratory preparation, lyophilised TB-500 is dissolved in bacteriostatic water: concentration in mg/mL equals the vial mass in mg divided by the millilitres of diluent added (e.g. a 5 mg vial in 2.5 mL gives 2 mg/mL). No human-use dosing instructions are provided.
What is the molecular weight and half-life of TB-500?
The TB-500 fragment (Ac-LKKTETQ, formula C₃₇H₆₆N₁₀O₁₄) has a molecular weight of 889.02 Da, far smaller than the 4921 Da full-length 43-amino-acid Thymosin Beta-4 it derives from. Rodent pharmacokinetics report a subcutaneous elimination half-life of roughly 1.5-3 hours, with peak plasma concentration (Cmax 200-400 ng/mL) reached 0.5-1 hour after dosing.
Why do researchers run the BPC-157 + TB-500 stack?
TB-500 and BPC-157 are studied together because they support tissue repair through different mechanisms: TB-500 through G-actin regulation, angiogenesis, and NF-κB modulation, and BPC-157 through the VEGFR2/eNOS pathway and growth-hormone-receptor upregulation. New-U Research Compounds supplies both as separate research-grade vials for laboratories investigating the combination.
Is TB-500 banned in sport?
Yes. TB-500 (and Thymosin Beta-4-related peptides) are on the World Anti-Doping Agency (WADA) prohibited list at all times.
What happens if you stop taking peptides?
It depends on the peptide. TB-500 (a Thymosin Beta-4 fragment) has a relatively short residence time, so once administration stops in a study the compound clears and no longer engages actin-binding and cell-migration pathways - observed tissue-repair processes lose ongoing stimulus rather than reversing abruptly. Unlike hormone-axis peptides, the research literature does not describe a suppression-rebound on cessation. These are preclinical research observations.
Research references
Independent literature and reference sources for TB-500. Provided for scientific context - New-U Research Compounds supplies research-use-only material.
Looking for mechanism of action, pharmacokinetics, dosage ranges and source references? See the full TB-500 research profile. Every compound profile is listed in the research peptide index.
Part of the Tissue repair & recovery research research area — explore related compounds, guides and sources.
PRECISION. PURITY. PERFORMANCE.
Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.
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[image: New-U Research Compounds logo and research peptide vial — Buy TB-500 at New-U Research Compounds]
[image: TB-500 research peptide vial — Healing / Recovery compound, >99% HPLC]