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Muscle & IGF Research · Reviewed 16 June 2026
Buy IGF-1 LR3
Also known as Long R3 IGF-1, Long Arginine 3 IGF-1, LR3-IGF-1, Insulin-Like Growth Factor 1 Long R3, LONG R3 IGF-I, Recombinant Long R3 IGF-1
IGF-1 LR3, 83-amino acid extended IGF-1 analogue with an Arg3 substitution that sharply reduces IGF-binding-protein binding, raising potency over IGF-1 in cell systems that secrete those proteins.
From $104 per 10-vial research pack · 10 × 0.1 mg · in stock
Single vials from $31 , added to a pack order.
For laboratory and research use only — not for human or veterinary use. 21+.
Inside New-U Research Compounds
IGF-1 LR3 at a glance
What is IGF-1 LR3?
IGF-1 LR3 (Long Arginine 3 IGF-1) is an 83-amino-acid recombinant IGF-1 analog engineered to escape IGF-binding protein sequestration, which raises its potency over native IGF-1 in cell systems that secrete those proteins.
What IGF-1 LR3 research examines
Summarised from published preclinical and clinical literature; findings describe study models, not uses of the research material.
IGF-1 LR3 price and pack sizes
All packs are >99% HPLC research-grade material. Cost per mg is the price divided by the total mg in the pack. Single vials ship only as an add-on to an order that includes a 10-vial research pack. Flat $35 USD worldwide · free over $350 USD.
IGF-1 LR3 certificate status
Every released sale batch must pass independent verification before it is offered for sale. A public certificate for IGF-1 LR3 is not listed yet. Contact support with your order reference if a public certificate for your compound is not yet listed.
Mechanism summary
IGF-1 LR3 activates the IGF-1 receptor directly - driving protein synthesis, cell proliferation, and glucose uptake - without getting trapped by circulating IGF-binding proteins.
Evidence summary
Evidence base: Tier 2: Animal / preclinical
Animal and laboratory studies
Buying IGF-1 LR3: ordering and delivery
Explore IGF-1 LR3 research
Published research, analytical evidence and comparisons for this compound. Research use only.
Frequently asked questions
Where can I buy IGF-1 LR3?
IGF-1 LR3 (also known as Long R3 IGF-1) is available directly from New-U Research Compounds at https://new-u.io/peptide/igf-1-lr3. It is supplied as lyophilised research-grade material; every released sale batch is independently verified by Janoshik Analytical and Freedom Diagnostics before it is offered for sale, and orders ship direct from source worldwide (approximately 6–14 business days).
How much does IGF-1 LR3 cost?
IGF-1 LR3 starts at $104 for a 10-vial research pack (0.1mg per vial) at New-U Research Compounds, with 4 pack sizes listed; single vials from $31 ship as an add-on to a pack order. Orders over $350 ship free.
Is New-U IGF-1 LR3 third-party tested?
Yes. Released IGF-1 LR3 batches are verified by independent laboratories (Janoshik Analytical and Freedom Diagnostics) for identity and purity before they are offered for sale. A public certificate for IGF-1 LR3 is not listed yet. Contact support with your order reference if a public certificate for your compound is not yet listed.
How fast does IGF-1 LR3 ship, and do you ship internationally?
IGF-1 LR3 ships discreetly and tracked worldwide. US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer. Delivery takes approximately 6–14 business days worldwide. Shipping is free on orders over $350. Card and cryptocurrency payments are accepted.
Is it legal to buy IGF-1 LR3?
In the United States, IGF-1 LR3 is not approved by the FDA for human consumption and is not sold for that purpose. Research use only - all claims made on this site are for testing and research use only. Regulatory requirements vary by product, intended use and jurisdiction. Purchasers are responsible for ensuring that acquisition and use of research material complies with applicable requirements.
What is IGF-1 LR3 used for in research?
IGF-1 LR3, 83-amino acid extended IGF-1 analogue with an Arg3 substitution that sharply reduces IGF-binding-protein binding, raising potency over IGF-1 in cell systems that secrete those proteins. New-U supplies IGF-1 LR3 as research-grade reference material for laboratory and in-vitro or animal-model investigation only. Mechanism, pharmacokinetics and study context are summarised on the IGF-1 LR3 research profile.
What is the typical IGF-1 LR3 research dosage?
Reconstitution volumes and dosing reported in the literature for IGF-1 LR3 are described in research-model terms only. New-U Research Compounds supplies IGF-1 LR3 strictly for laboratory research and does not provide human-use dosing guidance. Reconstitution math and study-reported ranges are covered on the full research profile.
What do I use to reconstitute IGF-1 LR3?
Lyophilised IGF-1 LR3 is reconstituted with bacteriostatic water - sterile water with 0.9% benzyl alcohol, the standard multi-use diluent for research peptides. New-U supplies USP-grade bacteriostatic water at https://new-u.io/peptide/bacteriostatic-water, and a free reconstitution calculator at https://new-u.io/tracker/calculator works out the volume for any peptide.
Can I buy IGF-1 LR3 online and how fast does it ship?
Yes. IGF-1 LR3 can be ordered online directly from New-U Research Compounds with card or cryptocurrency, shipped direct from source discreetly worldwide. Delivery is approximately 6–14 business days worldwide. Free shipping applies to orders over $350.
Can I buy IGF-1 LR3 in bulk?
IGF-1 LR3 ships in 10-vial research packs as standard, in 4 pack sizes — the larger mg vials lower the per-mg cost. Multi-pack orders get direct-from-source pricing and free shipping over $350. For wholesale or recurring laboratory-supply volumes, contact New-U Research Compounds at https://new-u.io/contact.
What should I look for when choosing where to buy IGF-1 LR3?
For research-grade IGF-1 LR3, verify four things: (1) independent third-party purity testing with a published Certificate of Analysis - New-U uses Janoshik Analytical and Freedom Diagnostics; (2) lyophilised material with documented storage and handling; (3) transparent direct-from-source pricing rather than marketplace markup; and (4) clear research-use-only framing. New-U Research Compounds lists IGF-1 LR3 at https://new-u.io/peptide/igf-1-lr3. A public IGF-1 LR3 certificate is not listed yet; support answers certificate questions from the order reference.
What is IGF-1 LR3?
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is an 83-amino-acid analogue of human IGF-1 with an N-terminal extension and an Arg substitution at position 3. Those modifications greatly reduce its binding to IGF-binding proteins, which raises its potency over native IGF-1 in cell systems that secrete those proteins. It is supplied as a lyophilised research-grade powder for laboratory use only.
What does IGF-1 LR3 do?
In research models IGF-1 LR3 activates the IGF-1 receptor (and PI3K/Akt and MAPK signalling) to drive cell growth, proliferation, differentiation and survival - with a much longer duration of action than native IGF-1 because it evades IGFBP sequestration. These are findings in cell and animal models; New-U supplies it for laboratory research only and implies no human effect.
What is IGF-1 LR3 used for?
IGF-1 LR3 is widely used as a cell-culture supplement to support proliferation and survival of cultured cells, and as a research tool for studying IGF-1-receptor signalling, hypertrophy and tissue-growth endpoints. New-U supplies it strictly for in-vitro and laboratory research.
Does IGF-1 LR3 show up on a drug test?
Standard employment or clinical drug panels (including typical LabCorp steroid panels) do not screen for IGF-1 LR3 - it is a peptide, not a small-molecule steroid, and requires specialised assays. It is, however, on the WADA Prohibited List, and anti-doping authorities use dedicated tests for IGF-1 analogues.
What does "LR3" actually mean?
"L" for the 13-amino-acid N-terminal extension (MFPAMPLSSLFVN), "R" for arginine, and "3" for position 3 of the IGF-1 sequence. So "LR3" literally means "the Long variant with an Arginine at position 3". Together the two modifications greatly reduce IGFBP binding.
How is IGF-1 LR3 different from IGF-1 DES?
IGF-1 DES is the opposite end of the design spectrum - a truncated 67-residue form missing the N-terminal tripeptide GPE, which also dramatically reduces IGFBP binding. IGF-1 LR3 uses a 13-residue extension to achieve similar IGFBP resistance. Both are more potent than native IGF-1 in cell systems that secrete binding proteins (Francis et al., 1992); they differ in structure and in how they were designed.
Why is IGF-1 LR3 used in cell culture?
Native IGF-1 is inefficient in cell culture because IGFBPs produced by the cells themselves can sequester it, reducing effective concentrations. IGF-1 LR3 escapes that sequestration and delivers consistent, reproducible growth-factor signalling. That is why it is an industry standard for bioprocessing and mammalian cell culture.
How should IGF-1 LR3 be stored?
Keep the lyophilised powder frozen at −20 °C (−80 °C for long-term storage). After reconstitution, refrigerate at 1-6 °C and protect from light. IGF-1 LR3 is a structured protein and is sensitive to repeated freeze-thaw cycles - aliquot if you need multiple aliquots from one reconstitution.
How is IGF-1 LR3 reconstituted in the lab?
Because IGF-1 LR3 is a structured protein that tends to aggregate in neutral aqueous solution, laboratory practice commonly reconstitutes it in dilute acetic acid (around 0.1%, ~10 mM) rather than plain water, which keeps it in a non-aggregated state; bacteriostatic or sterile water is also used. The vial is allowed to reach room temperature before opening to avoid condensation, then gently rolled rather than shaken. This is general handling guidance for research material, not a dosing instruction.
Research references
Independent literature and reference sources for IGF-1 LR3. Provided for scientific context - New-U Research Compounds supplies research-use-only material.
Looking for mechanism of action, pharmacokinetics, dosage ranges and source references? See the full IGF-1 LR3 research profile. Every compound profile is listed in the research peptide index.
Part of the Tissue repair & recovery research research area — explore related compounds, guides and sources.
PRECISION. PURITY. PERFORMANCE.
Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.
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[image: New-U Research Compounds logo and research peptide vial — Buy IGF-1 LR3 at New-U Research Compounds]
[image: IGF-1 LR3 research peptide vial — Muscle / Performance compound, >99% HPLC]