Shop by goal
Popular compounds
Research resources
Recently viewed
Other Research · Reviewed 16 June 2026
Buy Melanotan-1
Also known as Melanotan I, MT-1, Afamelanotide, NDP-MSH, NDP-α-MSH, [Nle4, D-Phe7]-α-MSH, CUV1647, Selective MC1R Agonist
Afamelanotide (Melanotan I) linear 13-amino-acid α-MSH analogue selectively activates MC1R eumelanogenesis via cAMP-MITF cascade.
From $114 per 10-vial research pack · 10 × 10 mg · in stock
Single vials from $34 , added to a pack order.
For laboratory and research use only — not for human or veterinary use. 21+.
Inside New-U Research Compounds
Melanotan-1 at a glance
What is Melanotan-1?
What Melanotan-1 research examines
Summarised from published preclinical and clinical literature; findings describe study models, not uses of the research material.
Melanotan-1 price and pack sizes
All packs are >99% HPLC research-grade material. Cost per mg is the price divided by the total mg in the pack. Single vials ship only as an add-on to an order that includes a 10-vial research pack. Flat $35 USD worldwide · free over $350 USD.
Melanotan-1 certificate status
Every released sale batch must pass independent verification before it is offered for sale. A public certificate for Melanotan-1 is not listed yet. Contact support with your order reference if a public certificate for your compound is not yet listed.
Mechanism summary
MT-1 selectively activates MC1R on melanocytes, turning on the cAMP/PKA/MITF cascade that drives eumelanin biosynthesis independently of UV exposure.
Evidence summary
Evidence base: Mixed (human + animal)
Human studies
Buying Melanotan-1: ordering and delivery
Explore Melanotan-1 research
Published research, analytical evidence and comparisons for this compound. Research use only.
Frequently asked questions
Where can I buy Melanotan-1?
Melanotan-1 (also known as Melanotan I) is available directly from New-U Research Compounds at https://new-u.io/peptide/melanotan-1. It is supplied as lyophilised research-grade material; every released sale batch is independently verified by Janoshik Analytical and Freedom Diagnostics before it is offered for sale, and orders ship direct from source worldwide (approximately 6–14 business days).
How much does Melanotan-1 cost?
Melanotan-1 starts at $114 for a 10-vial research pack (10mg per vial) at New-U Research Compounds, with 2 pack sizes listed; single vials from $34 ship as an add-on to a pack order. Orders over $350 ship free.
Is New-U Melanotan-1 third-party tested?
Yes. Released Melanotan-1 batches are verified by independent laboratories (Janoshik Analytical and Freedom Diagnostics) for identity and purity before they are offered for sale. A public certificate for Melanotan-1 is not listed yet. Contact support with your order reference if a public certificate for your compound is not yet listed.
How fast does Melanotan-1 ship, and do you ship internationally?
Melanotan-1 ships discreetly and tracked worldwide. US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer. Delivery takes approximately 6–14 business days worldwide. Shipping is free on orders over $350. Card and cryptocurrency payments are accepted.
Is it legal to buy Melanotan-1?
In the United States, Melanotan-1 is not approved by the FDA for human consumption and is not sold for that purpose. Research use only - all claims made on this site are for testing and research use only. Regulatory requirements vary by product, intended use and jurisdiction. Purchasers are responsible for ensuring that acquisition and use of research material complies with applicable requirements.
What is Melanotan-1 used for in research?
Afamelanotide (Melanotan I) linear 13-amino-acid α-MSH analogue selectively activates MC1R eumelanogenesis via cAMP-MITF cascade. New-U supplies Melanotan-1 as research-grade reference material for laboratory and in-vitro or animal-model investigation only. Mechanism, pharmacokinetics and study context are summarised on the Melanotan-1 research profile.
What is the typical Melanotan-1 research dosage?
Reconstitution volumes and dosing reported in the literature for Melanotan-1 are described in research-model terms only. New-U Research Compounds supplies Melanotan-1 strictly for laboratory research and does not provide human-use dosing guidance. Reconstitution math and study-reported ranges are covered on the full research profile.
What do I use to reconstitute Melanotan-1?
Lyophilised Melanotan-1 is reconstituted with bacteriostatic water - sterile water with 0.9% benzyl alcohol, the standard multi-use diluent for research peptides. New-U supplies USP-grade bacteriostatic water at https://new-u.io/peptide/bacteriostatic-water, and a free reconstitution calculator at https://new-u.io/tracker/calculator works out the volume for any peptide.
Can I buy Melanotan-1 online and how fast does it ship?
Yes. Melanotan-1 can be ordered online directly from New-U Research Compounds with card or cryptocurrency, shipped direct from source discreetly worldwide. Delivery is approximately 6–14 business days worldwide. Free shipping applies to orders over $350.
Can I buy Melanotan-1 in bulk?
Melanotan-1 ships in 10-vial research packs as standard, in 2 pack sizes — the larger mg vials lower the per-mg cost. Multi-pack orders get direct-from-source pricing and free shipping over $350. For wholesale or recurring laboratory-supply volumes, contact New-U Research Compounds at https://new-u.io/contact.
What should I look for when choosing where to buy Melanotan-1?
For research-grade Melanotan-1, verify four things: (1) independent third-party purity testing with a published Certificate of Analysis - New-U uses Janoshik Analytical and Freedom Diagnostics; (2) lyophilised material with documented storage and handling; (3) transparent direct-from-source pricing rather than marketplace markup; and (4) clear research-use-only framing. New-U Research Compounds lists Melanotan-1 at https://new-u.io/peptide/melanotan-1. A public Melanotan-1 certificate is not listed yet; support answers certificate questions from the order reference.
What is Melanotan-1?
Melanotan-1 (afamelanotide, MT-1) is a synthetic linear 13-amino-acid analogue of α-MSH ([Nle4,D-Phe7]-α-MSH, MW ~1647 Da) that selectively activates the melanocortin-1 receptor (MC1R) to drive eumelanin synthesis. It is the molecule approved as Scenesse (a 16 mg implant) for erythropoietic protoporphyria. New-U supplies it as a research-grade lyophilised powder for laboratory research use only - not the approved drug.
How is Melanotan-1 different from Melanotan-2?
MT-1 is a linear 13-amino-acid peptide that is relatively selective for MC1R (pigmentation). MT-2 is a cyclic 7-amino-acid peptide that hits all four melanocortin receptors non-selectively, which is why research reports it producing appetite suppression, nausea, and central arousal effects that MT-1 largely avoids. MT-1 is also the only one of the two FDA/EMA-approved for any indication.
What does the research on Melanotan-1 actually show?
The strongest data is in erythropoietic protoporphyria: a randomised phase 3 trial (Langendonk et al., NEJM 2015) reported that afamelanotide increased pain-free time in sunlight for EPP patients, which supported its EMA and FDA approval as Scenesse. Mechanistically, studies describe reliable MC1R-driven eumelanin accumulation without the central effects of non-selective analogues. This is summarised published research, not a human-use claim.
Does MT-1 work in people with fair skin or MC1R variants?
In the research literature, yes. Afamelanotide's clinical trial program tested populations carrying MC1R variant alleles (such as Val60Leu, Arg151Cys, and Arg160Trp) associated with weak natural pigmentation, and reported a pigmentation response even in those genotypes - one reason it was approved for EPP. Reported for research context only.
What is the half-life of Melanotan-1 described in the literature?
Published pharmacology describes a short plasma half-life of roughly 30 minutes after subcutaneous administration, but the studied biological pigmentation effect persists for several days because MC1R activation and slow receptor recycling outlast the circulating peptide. The Nle4 substitution prevents methionine oxidation and D-Phe7 resists proteolysis, extending activity versus native α-MSH. This is descriptive research context - not human-use dosing guidance.
What does "UV-independent" pigmentation actually mean?
Normal tanning requires UV damage - skin darkens as a response to DNA damage from sun exposure. MT-1 activates the same downstream pigmentation pathway (MC1R / cAMP / MITF / tyrosinase) directly at the receptor level, so in research models pigment accumulates without the upstream DNA-damage signal. The protective pigment is the same; only the trigger differs. Reported for research context only.
Is Melanotan-1 legal and FDA-approved?
The finished pharmaceutical afamelanotide (Scenesse) is FDA- and EMA-approved for erythropoietic protoporphyria - that approval applies to the prescription implant, NOT to research-grade powder. New-U's Melanotan-1 is an unapproved research compound supplied strictly for laboratory research; buyers are responsible for compliance in their own jurisdiction.
How should MT-1 be stored and reconstituted?
Keep the lyophilised powder frozen at −20 °C. For research preparation it is dissolved in bacteriostatic water; the reconstituted vial is then refrigerated at 1-6 °C and protected from light. The linear structure is slightly more sensitive than cyclic MT-2, so prompt use after reconstitution is preferable. This is laboratory handling information only, not a human-use instruction.
Research references
Independent literature and reference sources for Melanotan-1. Provided for scientific context - New-U Research Compounds supplies research-use-only material.
Looking for mechanism of action, pharmacokinetics, dosage ranges and source references? See the full Melanotan-1 research profile. Every compound profile is listed in the research peptide index.
Part of the Skin & cosmetic research research area — explore related compounds, guides and sources.
PRECISION. PURITY. PERFORMANCE.
Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
Shop
Research
Support
Ways to Pay
Shop by goal
Shop by compound
Shop by region
Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.
All rights reserved. Copyright of New-U held with Hilxera Distribution Services LLC 2026.
Website & business operated by Hilxera Distribution Services LLC. Registered in Wyoming, ID: 2026-001928701.
Principal office: 1712 Pioneer Ave., Ste. 500, Cheyenne, WY 82001, USA
© 2026 New-U Research Compounds · new-u.io
[image: New-U Research Compounds logo and research peptide vial — Buy Melanotan-1 at New-U Research Compounds]
[image: Melanotan-1 research peptide vial — Tanning / Libido compound, >99% HPLC]