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Other Research · Reviewed 16 June 2026
Buy Melanotan-2
Also known as Melanotan II, MT-2, MT-II, Melanotan 2, Non-Selective Melanocortin Agonist, Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂, Cyclic α-MSH Analogue
From $114 per 10-vial research pack · 10 × 10 mg · in stock
Single vials from $34 , added to a pack order.
For laboratory and research use only — not for human or veterinary use. 21+.
Inside New-U Research Compounds
Melanotan-2 at a glance
What is Melanotan-2?
What Melanotan-2 research examines
Summarised from published preclinical and clinical literature; findings describe study models, not uses of the research material.
Melanotan-2 price and pack sizes
All packs are >99% HPLC research-grade material. Cost per mg is the price divided by the total mg in the pack. Single vials ship only as an add-on to an order that includes a 10-vial research pack. Flat $35 USD worldwide · free over $350 USD.
Current Melanotan-2 certificate
The current published certificate for Melanotan-2 is an independent Janoshik Analytical report dated 28 April 2026.
Certificates of Analysis are published on the website — on each product page and at /coa — rather than packed with orders. Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.
Mechanism summary
Pharmacokinetics at a glance
Vss 0.2-0.5 L/kg; CL ~0.3 L/kg/h. Crosses the blood-brain barrier, producing both peripheral and central effects.
Evidence summary
Evidence base: Mixed (human + animal)
Human studies
Animal and laboratory studies
Buying Melanotan-2: ordering and delivery
Explore Melanotan-2 research
Published research, analytical evidence and comparisons for this compound. Research use only.
Frequently asked questions
Where can I buy Melanotan-2?
Melanotan-2 (also known as Melanotan II) is available directly from New-U Research Compounds at https://new-u.io/peptide/melanotan-2. It is supplied as lyophilised research-grade material; every released sale batch is independently verified by Janoshik Analytical and Freedom Diagnostics before it is offered for sale, and orders ship direct from source worldwide (approximately 6–14 business days).
How much does Melanotan-2 cost?
Melanotan-2 starts at $114 for a 10-vial research pack (10mg per vial) at New-U Research Compounds, with 2 pack sizes listed; single vials from $34 ship as an add-on to a pack order. Orders over $350 ship free.
Is New-U Melanotan-2 third-party tested?
Yes. Released Melanotan-2 batches are verified by independent laboratories (Janoshik Analytical and Freedom Diagnostics) for identity and purity before they are offered for sale. The current published certificate (Janoshik Analytical, 28 April 2026) reports 99.866% purity and is published at https://new-u.io/coa/melanotan-2.
How fast does Melanotan-2 ship, and do you ship internationally?
Melanotan-2 ships discreetly and tracked worldwide. US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer. Delivery takes approximately 6–14 business days worldwide. Shipping is free on orders over $350. Card and cryptocurrency payments are accepted.
Is it legal to buy Melanotan-2?
In the United States, Melanotan-2 is not approved by the FDA for human consumption and is not sold for that purpose. Research use only - all claims made on this site are for testing and research use only. Regulatory requirements vary by product, intended use and jurisdiction. Purchasers are responsible for ensuring that acquisition and use of research material complies with applicable requirements.
What is the typical Melanotan-2 research dosage?
Reconstitution volumes and dosing reported in the literature for Melanotan-2 are described in research-model terms only. New-U Research Compounds supplies Melanotan-2 strictly for laboratory research and does not provide human-use dosing guidance. Reconstitution math and study-reported ranges are covered on the full research profile.
What do I use to reconstitute Melanotan-2?
Lyophilised Melanotan-2 is reconstituted with bacteriostatic water - sterile water with 0.9% benzyl alcohol, the standard multi-use diluent for research peptides. New-U supplies USP-grade bacteriostatic water at https://new-u.io/peptide/bacteriostatic-water, and a free reconstitution calculator at https://new-u.io/tracker/calculator works out the volume for any peptide.
Can I buy Melanotan-2 online and how fast does it ship?
Yes. Melanotan-2 can be ordered online directly from New-U Research Compounds with card or cryptocurrency, shipped direct from source discreetly worldwide. Delivery is approximately 6–14 business days worldwide. Free shipping applies to orders over $350.
Can I buy Melanotan-2 in bulk?
Melanotan-2 ships in 10-vial research packs as standard, in 2 pack sizes — the larger mg vials lower the per-mg cost. Multi-pack orders get direct-from-source pricing and free shipping over $350. For wholesale or recurring laboratory-supply volumes, contact New-U Research Compounds at https://new-u.io/contact.
What should I look for when choosing where to buy Melanotan-2?
For research-grade Melanotan-2, verify four things: (1) independent third-party purity testing with a published Certificate of Analysis - New-U uses Janoshik Analytical and Freedom Diagnostics; (2) lyophilised material with documented storage and handling; (3) transparent direct-from-source pricing rather than marketplace markup; and (4) clear research-use-only framing. New-U Research Compounds meets all four at https://new-u.io/peptide/melanotan-2, and the current Melanotan-2 certificate is at https://new-u.io/coa/melanotan-2.
What is Melanotan-2?
Melanotan-2 (MT-2) is a synthetic cyclic heptapeptide analogue of α-MSH (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂, MW 1024.18 Da) that non-selectively activates the MC1R, MC3R, MC4R and MC5R melanocortin receptors. It is supplied as a lyophilised research-grade powder for laboratory use only - it is not approved for human use.
What does Melanotan-2 do?
In research models MT-2 activates MC1R to stimulate eumelanin synthesis (the pathway behind UV-independent pigmentation), and activates MC4R in the hypothalamus, which is associated with appetite suppression and arousal signalling. These are findings in animal/research models; New-U makes no human-use or cosmetic claims.
Does Melanotan-2 work without sun?
Because MT-2 stimulates melanocyte MC1R directly, melanogenesis can be triggered in research models with little or no UV exposure - unlike a normal tan that requires sunlight. Published observations note that UV exposure still substantially accelerates and deepens the studied pigmentation response. This is research context only, not a cosmetic or human-use recommendation.
Does Melanotan-2 change eye color?
There is no credible scientific evidence that MT-2 changes iris (eye) colour. The melanocytes it acts on are in the skin and hair; the documented pigmentation effects are darker skin and darkening of existing moles/freckles, not eye colour. Reported for research context only.
How is Melanotan-2 reconstituted?
Lyophilised MT-2 is dissolved in bacteriostatic water for multi-use research vials. Concentration in mg/mL equals the vial mass in mg divided by the millilitres of diluent added - e.g. a 10 mg vial reconstituted with 1 mL gives 10 mg/mL. Keep the reconstituted vial refrigerated at 1–6 °C and protected from light. This is laboratory preparation math only; no human-use dosing guidance is provided.
What is the difference between Melanotan-1 and Melanotan-2?
Melanotan-1 (afamelanotide) is a linear 13-amino-acid α-MSH analog that is more selective for MC1R and is EMA/FDA-approved as Scenesse for erythropoietic protoporphyria. Melanotan-2 is a smaller cyclic heptapeptide that activates MC1R, MC3R, MC4R, and MC5R non-selectively, producing broader effects and more side effects.
Why does Melanotan-2 cause nausea and facial flushing?
Those effects come from non-selective activation of MC4R and MC5R in the brain and exocrine glands. MC4R activation in hypothalamic nuclei drives both appetite suppression and nausea, while MC5R stimulates sebaceous secretion and vasomotor responses that show up as facial flushing.
How does Melanotan-2 relate to PT-141?
PT-141 (bremelanotide) is essentially an active metabolite of Melanotan-2 with a free carboxylic acid instead of an amide at the C-terminus. It is more selective for MC4R-mediated sexual arousal pathways and is FDA-approved as Vyleesi for generalised HSDD in premenopausal women.
How should Melanotan-2 be stored?
Keep lyophilised powder at −20 °C in the freezer. Once reconstituted with bacteriostatic water, refrigerate at 1-6 °C and protect from light. Reconstituted solutions are generally stable for several weeks under those conditions.
What Melanotan-2 dosage is described in research?
The research literature typically describes a low-microgram subcutaneous "loading" phase followed by smaller intermittent "maintenance" amounts, with melanogenesis driving the studied pigmentation response. New-U publishes this only as descriptive research context - it is not a dosing instruction.
What does Melanotan-2 before and after show in studies?
In pigmentation research, MC1R activation increases eumelanin synthesis, so studied endpoints describe a gradual darkening over roughly 1-4 weeks of repeated exposure that fades once dosing stops. Magnitude depends heavily on baseline skin type, amount and UV exposure. Reported for research context only - not a cosmetic or human-use claim.
How long does Melanotan-2 take to work and how long does it last?
Pigmentation is cumulative rather than immediate: pigmentation research describes a gradual darkening building over roughly 1-4 weeks of repeated low-dose exposure, then fading over weeks once dosing stops as melanocytes turn over. The peptide itself clears quickly (rodent IV half-life ~0.5-1.5 h) but the studied pigment effect outlasts the circulating compound. These are descriptive research-context observations, not human-use or cosmetic guidance.
What are the side effects of Melanotan-2 reported in research?
The literature most commonly reports nausea, facial flushing, appetite suppression and darkening of existing moles/freckles, arising from non-selective MC3R/MC4R/MC5R activation. New-U supplies Melanotan-2 as a research compound only and makes no safety or human-use claims; these are summarised research findings, not medical advice.
Is Melanotan-2 legal, and is it FDA-approved?
Melanotan-2 is not approved by the FDA, EMA or any major regulator for human use - only the related, more selective afamelanotide (Melanotan-1 / Scenesse) and bremelanotide (PT-141 / Vyleesi) hold approvals for specific indications. Melanotan-2 is sold in the US strictly as a research compound; buyers are responsible for compliance in their jurisdiction.
Research references
Independent literature and reference sources for Melanotan-2. Provided for scientific context - New-U Research Compounds supplies research-use-only material.
Looking for mechanism of action, pharmacokinetics, dosage ranges and source references? See the full Melanotan-2 research profile. Every compound profile is listed in the research peptide index.
Part of the Skin & cosmetic research research area — explore related compounds, guides and sources.
PRECISION. PURITY. PERFORMANCE.
Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.
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