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  • How-to guides
    New-U Research Compounds — Buy Semax at New-U Research Compounds. Laboratory research use only.

    Cognitive Research · Reviewed 16 June 2026

    Buy Semax

    Also known as ACTH(4-10)-Pro-Gly-Pro, Semax Heptapeptide, MEHFPGP, ACTH 4-10 Analogue, Semax Acetate, N-Acetyl Semax, Семакс

    From $93 per 10-vial research pack · 10 × 5 mg · in stock

    Single vials from $28 , added to a pack order.

  • View full research profile
  • Compare all 4 formats
  • Certificate of Analysis
  • For laboratory and research use only — not for human or veterinary use. 21+.

    Inside New-U Research Compounds

    Semax at a glance

    Sequence
    MEHFPGP
    Molecular weight
    813.92 Da
    Pathways studied
    BDNF / TrkB · Serotonergic tone · Dopaminergic modulation · Enkephalin enzyme inhibition
    Purity
    >99% HPLC
    Form
    Lyophilised powder
    Formats
    10-vial research packs and single vials · 5–10 mg per vial
    Latest certificate
    Janoshik Analytical, 23 June 2026 — 99.163% purity
    Laboratory storage
    Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation.

    What is Semax?

    What Semax research examines

  • Rapidly upregulates BDNF and TrkB receptor expression in hippocampal neurons
  • Modulates dopaminergic signaling with increased DA metabolite turnover in the striatum
  • Competitively antagonizes α-MSH at MC4 and MC5 melanocortin receptors
  • Inhibits enkephalin-degrading enzymes (IC₅₀ = 10 μM) to potentiate endogenous opioid signaling
  • Pro-Gly-Pro C-terminal extension independently modulates neurotrophin expression and immune signaling
  • Summarised from published preclinical and clinical literature; findings describe study models, not uses of the research material.

    Semax price and pack sizes

    Strength per vial Format Price Cost per mg 5 mg 10-vial research pack $93 $1.86 5 mg Single vial $28 $5.60 10 mg 10-vial research pack $149 $1.49 10 mg Single vial $41 $4.10

    All packs are >99% HPLC research-grade material. Cost per mg is the price divided by the total mg in the pack. Single vials ship only as an add-on to an order that includes a 10-vial research pack. Flat $35 USD worldwide · free over $350 USD.

    Current Semax certificate

    The current published certificate for Semax is an independent Janoshik Analytical report dated 23 June 2026.

    Laboratory Janoshik Analytical Report date 23 June 2026 Purity 99.163% Report number 196364 Earlier certificates on file 1
  • View the Semax certificate and testing history
  • Download the report (PDF)
  • How to read a Certificate of Analysis
  • Certificates of Analysis are published on the website — on each product page and at /coa — rather than packed with orders. Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.

    Mechanism summary

    Semax rapidly upregulates BDNF and TrkB in the hippocampus, tunes serotonin and dopamine neurotransmission, and activates enkephalin-dependent signalling - all from a brief plasma exposure.

    Target or pathway Reported activity Research significance BDNF / TrkB Rapidly upregulates BDNF and its receptor in the hippocampus Drives long-duration neurotrophic and cognitive effects Serotonergic tone Raises striatal 5-HIAA to 180% within 1-4 hours Supports mood, motivation, and cognitive flexibility Enkephalin enzyme inhibition Blocks enkephalin-degrading enzymes (IC50 ~10 μM) Potentiates endogenous opioid tone, contributing to mood effects Pro-Gly-Pro tail C-terminal extension Protects from proteolysis and has independent neurotrophic activity

    Evidence summary

    Evidence base: Mixed (human + animal)

    Animal and laboratory studies

  • Eremin et al. 2005 (Neurochemical Research) - activation of dopaminergic and serotonergic systems in rodents (striatal 5-HIAA to ~180%)
  • Buying Semax: ordering and delivery

    Delivery time
    Approximately 6–14 business days worldwide
    Dispatch
    Orders typically dispatch within 48 hours of confirmed payment.
    Ships from
    US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer.
    Shipping cost
    Flat $35 USD worldwide · free over $350 USD
    Payment
    Card, Apple Pay, Google Pay, Cash App, Cryptocurrency
    Packaging
    Discreet packaging
    In transit
    Lyophilised peptides are stable through the tracked transit window.
    Purchasers
    21+ · laboratory research use only

    Explore Semax research

    Published research, analytical evidence and comparisons for this compound. Research use only.

  • Research guide Semax research guide Semax rapidly upregulates BDNF and TrkB in the hippocampus, tunes serotonin and dopamine neurotransmission, and activates… Read the guide →
  • Analytical evidence View the Semax COA Current batch purity and identity testing, 2026-06-23. View the COA →
  • Related research FDA peptide review 2026: what the July meeting could mean for BPC-157, TB-500, Semax and Epitalon The FDA's Pharmacy Compounding Advisory Committee reviews BPC-157, KPV, TB-500, MOTS-c, Emideltide (DSIP), Semax and Epitalon on July… Read the article →
  • Related research Is Semax FDA approved? The 2026 regulatory status, explained No - Semax is not FDA approved in the US (though it is a registered medicine in Russia). It is supplied as a research-use-only compound… Read the article →
  • Frequently asked questions

    Where can I buy Semax?

    Semax (also known as ACTH(4-10)-Pro-Gly-Pro) is available directly from New-U Research Compounds at https://new-u.io/peptide/semax. It is supplied as lyophilised research-grade material; every released sale batch is independently verified by Janoshik Analytical and Freedom Diagnostics before it is offered for sale, and orders ship direct from source worldwide (approximately 6–14 business days).

    How much does Semax cost?

    Semax starts at $93 for a 10-vial research pack (5mg per vial) at New-U Research Compounds, with 4 pack sizes listed; single vials from $28 ship as an add-on to a pack order. Orders over $350 ship free.

    Is New-U Semax third-party tested?

    Yes. Released Semax batches are verified by independent laboratories (Janoshik Analytical and Freedom Diagnostics) for identity and purity before they are offered for sale. The current published certificate (Janoshik Analytical, 23 June 2026) reports 99.163% purity and is published at https://new-u.io/coa/semax.

    How fast does Semax ship, and do you ship internationally?

    Semax ships discreetly and tracked worldwide. US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer. Delivery takes approximately 6–14 business days worldwide. Shipping is free on orders over $350. Card and cryptocurrency payments are accepted.

    Is it legal to buy Semax?

    In the United States, Semax is not approved by the FDA for human consumption and is not sold for that purpose. Research use only - all claims made on this site are for testing and research use only. Regulatory requirements vary by product, intended use and jurisdiction. Purchasers are responsible for ensuring that acquisition and use of research material complies with applicable requirements.

    What is the typical Semax research dosage?

    Reconstitution volumes and dosing reported in the literature for Semax are described in research-model terms only. New-U Research Compounds supplies Semax strictly for laboratory research and does not provide human-use dosing guidance. Reconstitution math and study-reported ranges are covered on the full research profile.

    What do I use to reconstitute Semax?

    Lyophilised Semax is reconstituted with bacteriostatic water - sterile water with 0.9% benzyl alcohol, the standard multi-use diluent for research peptides. New-U supplies USP-grade bacteriostatic water at https://new-u.io/peptide/bacteriostatic-water, and a free reconstitution calculator at https://new-u.io/tracker/calculator works out the volume for any peptide.

    Can I buy Semax online and how fast does it ship?

    Yes. Semax can be ordered online directly from New-U Research Compounds with card or cryptocurrency, shipped direct from source discreetly worldwide. Delivery is approximately 6–14 business days worldwide. Free shipping applies to orders over $350.

    Can I buy Semax in bulk?

    Semax ships in 10-vial research packs as standard, in 4 pack sizes — the larger mg vials lower the per-mg cost. Multi-pack orders get direct-from-source pricing and free shipping over $350. For wholesale or recurring laboratory-supply volumes, contact New-U Research Compounds at https://new-u.io/contact.

    What should I look for when choosing where to buy Semax?

    For research-grade Semax, verify four things: (1) independent third-party purity testing with a published Certificate of Analysis - New-U uses Janoshik Analytical and Freedom Diagnostics; (2) lyophilised material with documented storage and handling; (3) transparent direct-from-source pricing rather than marketplace markup; and (4) clear research-use-only framing. New-U Research Compounds meets all four at https://new-u.io/peptide/semax, and the current Semax certificate is at https://new-u.io/coa/semax.

    What is Semax and how does it work?

    Semax is a synthetic seven-amino-acid (heptapeptide) analogue of ACTH(4-10) with a Pro-Gly-Pro tail, studied as a nootropic and neuroprotective research compound. In animal models it rapidly raises BDNF and TrkB signalling in the hippocampus and modulates serotonin and dopamine neurotransmission, which is the mechanistic basis for the cognition and mood endpoints reported in the literature. New-U supplies it for laboratory research only.

    What does the Semax research actually show?

    The most cited preclinical findings are neurotrophic and monoaminergic. A single dose of Semax increased hippocampal BDNF protein and TrkB phosphorylation in rats (Dolotov et al., 2006), and Semax raised striatal extracellular 5-HIAA to roughly 180% in a 1-4 hour window in rodents (Eremin et al., 2005). Most positive cognitive and stroke-recovery data come from Russian clinical and animal studies; these are research findings, not a promise of any effect in humans.

    What is the half-life of Semax and how long does it last?

    Published pharmacology describes a short plasma half-life (on the order of minutes) but a much longer functional window, because the BDNF/TrkB upregulation it triggers persists after the peptide itself has cleared. This is why the literature often separates Semax's circulating half-life from its downstream effect duration. We describe these figures descriptively from the research and make no dosing recommendation.

    Is Semax legal, and is it FDA-approved?

    Semax is not FDA-approved in the United States and is sold strictly as a research chemical for laboratory use - it is not approved for human consumption here. It is, however, a registered/approved medicine in Russia (and reportedly Ukraine) for indications such as ischemic stroke and cognitive disorders. Legal status varies by jurisdiction, so confirm your local rules before purchasing.

    Why is intranasal used instead of injection in Semax research?

    Intranasal delivery uses the olfactory pathway to reach the brain quickly, which suits a peptide with a short plasma half-life that needs to act centrally. Russian clinical formulations are typically nasal drops; subcutaneous administration also appears in the literature. The route choice is about getting peptide to brain tissue efficiently, not a recommendation on how anyone should dose it.

    Does Semax have ACTH-like effects on cortisol?

    No - the ACTH(4-10) fragment carries the neurotropic activity of ACTH but lacks the adrenal-stimulating portion of the full hormone, so it does not act as a meaningful cortisol stimulus. That separation of neurotrophic activity from hormonal activity was a deliberate design choice and is one reason Semax is studied as a cognition tool rather than a hormone.

    How is Semax different from Selank, and from Noopept?

    Semax and Selank are both Russian Pro-Gly-Pro heptapeptides given intranasally, but from different parents: Semax is ACTH(4-10)-derived and emphasises cognition and neuroprotection, while Selank is tuftsin-derived and emphasises anxiolysis - they are sometimes studied together. Noopept is an unrelated small-molecule (a dipeptide-like racetam derivative), not a true peptide, so it is a different chemical class entirely despite the overlapping nootropic research interest.

    How should Semax be stored?

    Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The Pro-Gly-Pro tail makes Semax noticeably more stable than ACTH(4-10) alone, but standard peptide handling still applies - avoid repeated freeze-thaw cycles.

    Research references

    Independent literature and reference sources for Semax. Provided for scientific context - New-U Research Compounds supplies research-use-only material.

  • Semax — Wikipedia
  • Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research.
  • Eremin KO, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochemical Research.
  • Looking for mechanism of action, pharmacokinetics, dosage ranges and source references? See the full Semax research profile. Every compound profile is listed in the research peptide index.

    Part of the Cognitive & longevity research research area — explore related compounds, guides and sources.

    PRECISION. PURITY. PERFORMANCE.

    Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.

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  • Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.

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    © 2026 New-U Research Compounds · new-u.io

    [image: New-U Research Compounds logo and research peptide vial — Buy Semax at New-U Research Compounds]

    [image: Semax research peptide vial — Cognitive / Neuro compound, >99% HPLC]

    Research use only — not for human consumption. All products are supplied strictly for laboratory research purposes.

    © 2026 New-U Research Compounds · new-u.io — Copyright held with Hilxera Distribution Services LLC. All rights reserved.